Opioid-related overdose and chronic use following an initial prescription of hydrocodone versus oxycodone.

Scott G WeinerMichelle A HendricksSanae El IbrahimiGrant A RitterSara E HallvikChristi HildebranRoger D WeissEdward W BoyerDiana P FloresLewis S NelsonPeter W KreinerMichael A Fischer

Published in: PloS one (2022)

Among previously opioid-naïve patients, the risk of developing chronic use was slightly higher with hydrocodone, whereas the risk of overdose was higher after oxycodone, in combination with acetaminophen or monotherapy. With a goal of reducing overdose-related deaths, hydrocodone may be the favorable agent.

Keyphrases

chronic pain
pain management
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
clinical trial
patient reported outcomes
study protocol