TLR4 sensing of IsdB of Staphylococcus aureus induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade.
Juan José Izquierdo GonzalezMd Faruq HossainJolanda NeefErin E ZwackChih-Ming TsaiDina RaafatKevin FechtnerLuise HerzogThomas P KohlerRabea SchlüterAlexander RederSilva HoltfreterGeorge Y LiuSven HammerschmidtUwe VölkerVictor J TorresJan Maarten van DijlChristopher H LilligBarbara M BrökerMurthy N DarisipudiPublished in: mBio (2023)
modulates the immune response, which is necessary for vaccine development against the sophisticated pathogen.