In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT.

Emilio Di IanniJohanna Samulin ErdemPeter MøllerNicklas Mønster SahlgrenSarah Søs PoulsenKristina Bram KnudsenShan ZienolddinyAnne Thoustrup SaberHåkan WallinUlla VogelNicklas Raun Jacobsen

Published in: Particle and fibre toxicology (2021)

This study shows correlations of pro-inflammatory potential in A549 and THP-1a cells with neutrophil influx in mice, and concordance in genotoxic response between THP-1a cells and BAL cells, for seven MWCNT.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
pulmonary hypertension
oxidative stress
metabolic syndrome
skeletal muscle
climate change