Efficacy and safety of recombinant human soluble thrombomodulin in patients with sepsis-associated coagulopathy: A systematic review and meta-analysis.

Emanuele ValerianiAlessandro SquizzatoAndrea GalloEttore PorrecaJean-Louis VincentToshiaki IbaAkiyoshi HagiwaraMarcello Di Nisio

Published in: Journal of thrombosis and haemostasis : JTH (2020)

In patients with sepsis, SAC is associated with higher 28-day mortality. The administration of rhsTM reduced 28-day mortality in patients with SAC, but not in those without SAC.

Keyphrases

recombinant human
acute kidney injury
cardiovascular events
septic shock
intensive care unit
risk factors
cardiovascular disease