Platelet-rich plasma activates AKT signaling to promote wound healing in a mouse model of radiation-induced skin injury.

Janet LeeHyosun JangSunhoo ParkHyunwook MyungKyuchang KimHyewon KimWon-Suk JangSun-Joo LeeJae Kyung MyungSehwan Shim

Published in: Journal of translational medicine (2019)

Our findings indicate that PRP enhances the functions of K14 cells via AKT signaling, accelerating the regeneration of irradiated skin. These wound-healing benefits may have merit in a clinical setting.

Keyphrases

wound healing
platelet rich plasma
radiation induced
mouse model
signaling pathway
induced apoptosis
cell proliferation
radiation therapy
cell cycle arrest
stem cells
oxidative stress
soft tissue