The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment.
Hong HongKai ZengCan ZhouXiaochuan ChenZhezhen XuMengjie LiLu LiuQian ZengQian TaoXi WeiPublished in: Stem cell research & therapy (2023)
OCT4A was found to be a crucial factor maintaining the self-renewal of hDPSCs by transcriptionally targeting FTX in an inflammatory microenvironment. Moreover, we proposed a novel function of FTX in negatively regulating the pluripotency and multilineage differentiation capacity of hDPSCs. The hierarchical organization between OCT4A and FTX expanded the understanding of the network between transcription factors and lncRNAs in fine-tuning the pluripotency/differentiation balance of adult stem cells, and provided prospective targets for optimizing dental-derived stem cell sources for regenerative endodontics.
Keyphrases
- stem cells
- lps induced
- optical coherence tomography
- diabetic retinopathy
- inflammatory response
- transcription factor
- endothelial cells
- oxidative stress
- cell therapy
- optic nerve
- embryonic stem cells
- long non coding rna
- drinking water
- air pollution
- mesenchymal stem cells
- induced pluripotent stem cells
- cancer therapy
- oral health
- network analysis
- bone marrow
- genome wide identification