Antiprotozoal Isoprenoids from Salvia hydrangea.
Marzieh TabefamMahdi Moridi FarimaniOmbeline DantonJustine RamseyerSamad Nejad EbrahimiMarkus NeuburgerMarcel KaiserPeyman SalehiOlivier PotteratMatthias HamburgerPublished in: Journal of natural products (2018)
Fractionation of the n-hexane extract of Salvia hydrangea afforded seven isoprenoids including six new compounds (1-6) and salvadione A (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS). The absolute configuration of salvadione A (7) was established by single-crystal X-ray diffraction analysis with Cu/Kα radiation. In addition, the absolute configuration of all compounds was determined by electronic circular dichroism spectroscopy. A biosynthetic pathway for the formation of the scaffold of 1 is proposed. The antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum was determined, and cytotoxicity was assessed in rat myoblast L6 cells. Perovskone C (2) exhibited good activity against P. falciparum (IC50 0.6 μM) and a selectivity index of 62.2.
Keyphrases
- data analysis
- high resolution
- plasmodium falciparum
- trypanosoma cruzi
- induced apoptosis
- oxidative stress
- cell cycle arrest
- magnetic resonance imaging
- computed tomography
- endoplasmic reticulum stress
- anti inflammatory
- mass spectrometry
- tissue engineering
- signaling pathway
- cell proliferation
- dual energy
- ms ms
- metal organic framework
- molecular dynamics simulations