Intraindividual variability of serum aldosterone and its implication for primary aldosteronism screening.
Ana Alice W MacielThais C FreitasGustavo F C FagundesJanaina PetenuciLeticia A P VilelaLuciana P BritoTatiana S GoldbaumMaria Claudia N ZerbiniFelipe L LedesmaFabio Y TannoVictor SrougiJose L ChamboMaria Adelaide A PereiraFernando M A CoelhoAline C B S CavalcanteFrancisco C CarnevaleBruna PilanAndrea Pio-AbreuJoão V SilveiraFernanda M Consolim-ColomboLuiz A BortolottoAna Claudia LatronicoMaria Candida Barisson Villares FragosoLuciano F DragerBerenice B MendoncaMadson Queiroz AlmeidaPublished in: The Journal of clinical endocrinology and metabolism (2022)
Aldosterone concentrations had a high CV in PA patients, which results in an elevated rate of false negative test in a single screening for PA. Therefore, PA screening should be based in at least two screenings with concomitant aldosterone and renin measurements.