Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers.

Bernardo P de AlmeidaJoana Dias ApolónioAlexandra BinniePedro Castelo-Branco

Published in: BMC cancer (2019)

We have identified 368 DNA methylation changes that characterize breast cancer tumor tissue, of which 209 are associated with genes that are differentially-expressed in the same samples. Novel DNA methylation markers were identified, of which cg12374721 (PRAC2), cg18081940 (TDRD10) and cg04475027 (TMEM132C) show promise as diagnostic and prognostic markers in breast cancer as well as other cancer types.

Keyphrases

dna methylation
genome wide
gene expression
copy number
papillary thyroid
squamous cell carcinoma
childhood cancer
young adults
big data
squamous cell
lymph node metastasis
transcription factor
artificial intelligence