Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury.
Andrea FerrignoGiuseppina PalladiniLaura Giuseppina Di PasquaClarissa BerardoPlinio RichelmiMassimiliano CadamuroLuca FabrisStefano PerliniLuciano AdoriniGiuseppina PalladiniPublished in: PloS one (2020)
Thus, OCA administration confers protection to cholangiocytes via downregulation of biliary MMPs in livers submitted to I/R. This event is associated with hepatic RECK- and TIMP-mediated MMP decrease.