Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking.
Bowen TangQianwen LiuAnna IlarPernilla WiebertSara HäggLeonid PadyukovLars KlareskogLars AlfredssonXia JiangPublished in: Annals of the rheumatic diseases (2022)
Occupational inhalable agents could act as important environmental triggers in RA development and interact with smoking and RA-risk genes leading to excessive risk for ACPA-positive RA. Future studies are warranted to assess preventive strategies aimed at reducing occupational hazards and smoking, especially among those who are genetically vulnerable.
Keyphrases
- rheumatoid arthritis
- disease activity
- smoking cessation
- ankylosing spondylitis
- interstitial lung disease
- genome wide
- systemic lupus erythematosus
- gene expression
- climate change
- current status
- systemic sclerosis
- weight gain
- physical activity
- copy number
- body mass index
- transcription factor
- idiopathic pulmonary fibrosis