Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool for Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis.

Judith WienkeLauren M PachmanGabrielle A MorganJoo Guan YeoMaria C AmorusoVictoria HansSylvia S M KamphuisEsther P A H HoppenreijsWineke ArmbrustJ Merlijn van den BergPetra C E Hissink MullerKyra A GeldermanThaschawee ArkachaisriFemke van WijkAnnet van Royen-Kerkhof

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Results of this study confirm the heterogeneity of new-onset juvenile DM based on serum biomarker profiles. Patients with high serum levels of galectin-9, CXCL10, TNFRII, and galectin-1 may respond suboptimally to conventional treatment, and may therefore benefit from more intensive monitoring and/or treatment.

Keyphrases

single cell
interstitial lung disease
skeletal muscle
systemic sclerosis
disease activity
glycemic control