Effects of tenofovir on telomeres, telomerase and T cell maturational subset distribution in long-term aviraemic HIV-infected adults.

Javier Rodríguez-CentenoAndrés Esteban-CantosRocío MontejanoNatalia Stella-AscarizRosa De MiguelBeatriz Mena-GarayGabriel Saiz-MedranoBelén AlejosMaría Jiménez-GonzálezJose Ignacio BernardinoJulen CadiñanosJuan M Castro-AlvarezBerta RodésJose Ramon Arribas

Published in: The Journal of antimicrobial chemotherapy (2022)

In long-term aviraemic HIV adults, the inhibition of telomerase by tenofovir could explain telomere shortening in CD8+ T cells. There is no telomere shortening in the CD4+ compartment and the decrease in telomerase activity could be explained both by the inhibition by tenofovir and by the lower proportion of RTE CD4+cells.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv aids
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
hiv testing