FGF21 response to sucrose is associated with BMI and dorsal striatal signaling in humans.
Jasmin Marie AlvesAlexandra G YunkerShan LuoKay JannBrendan AngeloAlexis DeFendisTrevor A PickeringAlexandro SmithJohn R MonterossoKathleen Alanna PagePublished in: Obesity (Silver Spring, Md.) (2022)
These correlative findings support evidence in animals showing that FGF21 acts on the brain to regulate sugar consumption through a negative feedback loop.