Login / Signup

A Selective Culture Medium for Screening Ceftazidime-Avibactam Resistance in Enterobacterales and Pseudomonas aeruginosa.

Mustafa SadekLaurent PoirelCamille TinguelyPatrice Nordmann
Published in: Journal of clinical microbiology (2020)
The SuperCAZ/AVI medium was developed for screening ceftazidime-avibactam (CZA) resistance among Gram-negative bacteria (Enterobacterales and Pseudomonas aeruginosa). It was evaluated using 50 CZA-susceptible and 42 CZA-resistant Gram-negative isolates. Its sensitivity and specificity of detection were 100%. Excellent performance of the medium was also observed by testing spiked stools, with the lower limit of detection ranging from 101 to 102 CFU/ml. This screening medium provides the opportunity to detect CZA-resistant isolates regardless of their resistance mechanisms.
Keyphrases
  • gram negative
  • multidrug resistant
  • pseudomonas aeruginosa
  • acinetobacter baumannii
  • cystic fibrosis
  • drug resistant
  • klebsiella pneumoniae
  • label free
  • real time pcr
  • quantum dots