A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice.
Aline Dias de AlmeidaIrismara Sousa SilvaWeslley Fernandes-BragaAntônio Carlos Melo LimaFilhoR Odrigo Machado FlorentinoAyslan BarraLuciana de Oliveira AndradeM Fátima LeiteGeovanni Dantas CassaliAndré KleinPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)
Our study provides, for the first time, evidence of a pivotal role for MCs and MC tryptase in neutrophil migration, lung inflammation and macrophage activation triggered by LPS, by a mechanism dependent on PAR2 activation.