Evaluation of neuroprotective and anti-amnesic effects of Elaeagnus umbellata Thunb. On scopolamine-induced memory impairment in mice.

Nausheen NazirMuhammad ZahoorMohammad NisarNasiara KarimAbdul LatifSajjad AhmadZia Uddin

Published in: BMC complementary medicine and therapies (2020)

The data obtained from behavioral and biochemical studies (AChE/BChE and DPPH/ABTS inhibition) have shown that E. umbellata possessed significant memory enhancing potency. These results suggest that E. umbellata extract possess potential antiamnesic effects and amongst the isolated compounds, compound I could be more effective anti-amnesic therapeutics. However, further studies are needed to identify the exact mechanism of action.

Keyphrases

working memory
case control
oxidative stress
high glucose
small molecule
diabetic rats
electronic health record
type diabetes
big data
metabolic syndrome
drug induced
adipose tissue
machine learning
insulin resistance
deep learning
stress induced
wild type