Phosphorylated tau in plasma could be a biomarker of lower motor neuron impairment in amyotrophic lateral sclerosis.
Federico VerdeIlaria MiloneEleonora ColomboAlessio MaranzanoAntonella DubiniClaudia ColombritaFrancesco GentileAlberto DorettiSilvia TorreStefano MessinaClaudia MorelliErminio TorresaniBarbara PolettiAlberto PrioriLuca MadernaAntonia RattiVincenzo SilaniNicola TicozziPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
pP-tau181 has potential as ALS biomarker and could be associated with LMN impairment. Its raised levels might reflect pathophysiological processes (tau hyperphosphorylation and/or release) occurring in the axons of LMNs distantly from the CNS and the CSF. pP-tau181 could also be associated with respiratory dysfunction.