Designing a multifunctional staphylokinase variant (SAK-2RGD-TTI) with appropriate thrombolytic activity in vitro.

Habibollah FarajiFatemeh SoltaniMohammad RamezaniHamid Reza SadeghniaReza NedaeiniaHamid Moghimi BenhangiBaratali Mashkani

Published in: Biotechnology letters (2019)

Our findings suggest that SAK-2RGD-TTI has improved therapeutic properties preventing reocclussion. It further confirms that it is practicable to assemble and produce a hybrid multifunctional protein that targets hemostatic process at various stages.

Keyphrases

drug delivery
cancer therapy
pulmonary embolism
metal organic framework
acute ischemic stroke
protein protein
binding protein
small molecule