Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation.

Emily J KollerKristen R IbanezQuan VoKaren N McFarlandElsa Gonzalez De La CruzLillian ZobelTristan WilliamsGuilian XuDaniel RyuPreya PatelBenoit I GiassonStefan ProkopParamita Chakrabarty

Published in: Neuropathology and applied neurobiology (2021)

Our data show that different tau mutations representing specific folding variants of tau synergise with Aβ to different extents, depending on the presence of cerebral deposits.

Keyphrases

cerebrospinal fluid
copy number
electronic health record
subarachnoid hemorrhage
single molecule
big data
machine learning
dna methylation
deep learning
artificial intelligence
cerebral blood flow