Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.
James F ColbertJoshua M KirschChristopher L ErzenChristophe J Langouët-AstriéGrace E ThompsonSarah A McMurtryJennifer M KofonowCharles E RobertsonElizabeth J KovacsRyan C SullivanJoseph A HippensteelNamrata V SawantNicole J De NiscoBruce D McCollisterRobert S SchwartzAlexander R HorswillDaniel N FrankBreck A DuerkopEric P SchmidtPublished in: bioRxiv : the preprint server for biology (2023)
The severity of sepsis in the aged host is in part mediated by longevity-associated increases in gut microbial virulence.