Hypoxia alleviates dexamethasone-induced inhibition of angiogenesis in cocultures of HUVECs and rBMSCs via HIF-1α.

Miaomiao ChaiCe GuQihua ShenJiaxing LiuYi ZhouZiyang JinWanli XiongYan ZhouWensong Tan

Published in: Stem cell research & therapy (2020)

Coculture of hypoxia-preconditioned HUVECs and MSCs showed robust angiogenesis and osteogenesis in OIM, which has important implications for prevascularization in bone tissue engineering in the future.

Keyphrases

endothelial cells
high glucose
tissue engineering
vascular endothelial growth factor
mesenchymal stem cells
bone regeneration
bone mineral density
current status
diabetic rats
low dose
umbilical cord
soft tissue
oxidative stress
bone loss
drug induced
wound healing
stress induced