Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm.
Paul LoickGoran Hamid MohammadIsmail I CassimjeeAnirudh ChandrashekarPierfrancesco LapollaAlison CarringtonMayra Vera-AvilesAshok HandaRegent LeeSamira Lakhal-LittletonPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Hepcidin elevation in SMCs plays a protective role in the setting of AAA. These findings are the first demonstration of a protective rather than deleterious role for hepcidin in cardiovascular disease. They highlight the need to further explore the prognostic and therapeutic value of hepcidin outside disorders of iron homeostasis.