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Mesenchymal Stem Cells Protect Nucleus Pulposus Cells from Compression-Induced Apoptosis by Inhibiting the Mitochondrial Pathway.

Sheng ChenLei ZhaoXiangyu DengDeyao ShiFashuai WuHang LiangDonghua HuangZeng-Wu Shao
Published in: Stem cells international (2017)
Our results suggest that BMSCs can protect against compression-induced apoptosis of NPCs by inhibiting the mitochondrial pathway and thus enhance our understanding on the MSC-based therapy for IVDD.
Keyphrases
  • induced apoptosis
  • signaling pathway
  • oxidative stress
  • endoplasmic reticulum stress
  • mesenchymal stem cells
  • bone marrow
  • umbilical cord
  • cell therapy