Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy.
Prakhar SengarPatricia JuárezAndrea Verdugo-MezaDanna L ArellanoAkhil JainKanchan ChauhanGustavo A HirataPierrick G J FournierPublished in: Journal of nanobiotechnology (2018)
Our results indicate that YPMS@PpIX@FA nanocomposites are promising candidates for X-ray-mediated PDT of deep-seated tumors. The design of these nanoparticles allows the functionalization with exchangeable targeting ligands thus offering versatility, in order to target various cancer cells, expressing different molecular targets on their surface.
Keyphrases
- photodynamic therapy
- quantum dots
- reduced graphene oxide
- papillary thyroid
- fluorescence imaging
- high resolution
- carbon nanotubes
- squamous cell
- cancer therapy
- visible light
- fluorescent probe
- magnetic resonance imaging
- single molecule
- computed tomography
- magnetic resonance
- drug delivery
- mass spectrometry
- lymph node metastasis
- energy transfer
- combination therapy
- smoking cessation