Stromal cell-derived factor-1 downregulation contributes to neuroprotection mediated by CXC chemokine receptor 4 interactions after intracerebral hemorrhage in rats.

Yu WuZhuwei ZhangXiao-Ou SunJing WangHai-Tao Shen Xue SunZhong Wang

Published in: CNS neuroscience & therapeutics (2023)

This study indicated that inhibition of SDF-1/CXCR4 complex formation can rescue the inflammatory response and alleviate neurobehavioral dysfunction after ICH. SDF-1/CXCR4 may have applications as a therapeutic target after ICH.

Keyphrases

inflammatory response
brain injury
cell proliferation
bone marrow
cell migration
lipopolysaccharide induced
lps induced
immune response
cerebral ischemia
subarachnoid hemorrhage