OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.

Yizhou FengYuan YuanHongxia XiaZhaopeng WangYan CheZhefu HuJiangyang DengFangfang LiQingqing WuZhouyan BianHeng ZhouDifei ShenQi-Zhu Tang

Published in: Journal of translational medicine (2023)

OSMR deficiency aggravated pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling, which provided evidence that OSMR might be an attractive target for treating pathological cardiac hypertrophy and heart failure.

Keyphrases

heart failure
diabetic rats
high glucose
cell proliferation
signaling pathway
left ventricular
oxidative stress
atrial fibrillation