Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier.

Senani N H RathnayakeBenedikt DitzJos van NijnattenTayyaba SadafPhilip Michael HansbroCorry A BrandsmaHidde J HaismaAnnemarie van SchadewijkPieter S HiemstraNick H T Ten HackenBrian Gregory George Oliver Huib A M Kerstjens Maarten van den Berge Alen Faiz

Published in: Respirology (Carlton, Vic.) (2022)

Smoking alters bronchial-mucus-barrier cell composition, transcriptome and increases mucus production. This effect is partly reversible within a year of smoking cessation. CD methodology can predict goblet-cell percentages from RNA-seq.

Keyphrases

single cell
rna seq
smoking cessation
replacement therapy
cell therapy
genome wide