Stromal-like Cells Are Found in Peripheral Blood of Inflammatory Bowel Disease Patients and Correlate with Immune Activation State.

Amanda M HonanGillian E JacobsenHannah DrumEmily N VazquezMaria A QuinteroAmar R DeshpandeDaniel A SussmanDavid H KermanOriana M DamasSiobhan ProksellKevin Van der JeughtMaria T AbreuZhibin Chen

Published in: Clinical and translational gastroenterology (2024)

These observations suggest that PDPN+ cells in the blood may serve as a biomarker of IBD. Understanding the relationship between stromal cells and immune cells in the intestine and the blood may provide a window into disease pathogenesis and insight into therapeutic targets for IBD.

Keyphrases

peripheral blood
end stage renal disease
newly diagnosed
induced apoptosis
chronic kidney disease
ejection fraction
peritoneal dialysis
ulcerative colitis
prognostic factors
cell cycle arrest
signaling pathway
cell death
oxidative stress
patient reported outcomes