Determination of nitroimidazole antibiotics based on dispersive solid-phase extraction combined with capillary electrophoresis.
Jing YangLianfang ChenQingying WangXiaolin MeiXiu-Pei YangFeng HuoPublished in: Electrophoresis (2022)
For a long time, the detection of nitroimidazole antibiotics (NIABs) has been a research focus in environmental analytical chemistry. In this work, a novel technique for the analysis of nitroimidazoles was established based on capillary electrophoresis (CE). UiO-66, synthesized using a solvothermal method, was utilized as an adsorbent in the dispersive solid-phase extraction (DSPE) of five different NIABs. The separation and detection of NIABs in environmental water samples were accomplished using the CE diode array detection method. The optimal extraction conditions were obtained after systematically studying the effects of adsorption time, the amount of extractant, and elution solvent on extraction efficiency. According to the results of the study, the limit of detections of the five NIABs were between 16 and 97 ng/mL, the relative standard deviations were between 0.32% and 0.55%, and the spike recoveries were between 87.43% and 104.8%. This study presents a novel technique for measuring NIABs in complex water samples.
Keyphrases
- solid phase extraction
- liquid chromatography
- capillary electrophoresis
- mass spectrometry
- high performance liquid chromatography
- molecularly imprinted
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- gas chromatography mass spectrometry
- simultaneous determination
- ultra high performance liquid chromatography
- gas chromatography
- high resolution mass spectrometry
- loop mediated isothermal amplification
- label free
- real time pcr
- climate change
- metal organic framework