AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system.

Jingyue JiaBhawana BissaLukas BrechtLee AllersSeong Won ChoiYuexi Gu Mark ZbindenMark R BurgeGraham TimminsKenneth HallowsChristian Behrends Vojo P Deretic

Published in: Autophagy (2020)

AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; CAMKK2: calcium/calmodulin dependent protein kinase kinase 2; DUB: deubiquitinase; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K7/TAK1: mitogen-activated protein kinase kinase kinase 7; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; STK11/LKB1: serine/threonine kinase 11; TNFSF10/TRAIL: TNF superfamily member 10; USP9X: ubiquitin specific peptidase 9 X-linked.

Keyphrases

protein kinase
oxidative stress
endoplasmic reticulum stress
rheumatoid arthritis
mesenchymal stem cells
simultaneous determination
cell proliferation
nitric oxide
skeletal muscle
tyrosine kinase
bone marrow
high density