ITPA:c.94C>A and NUDT15:c.415C>T Polymorphisms and Their Relation to Mercaptopurine-Related Myelotoxicity in Childhood Leukemia in Thailand.

Boonchai Boonyawat Chalinee Monsereenusorn Apichat PhotiaNawachai LertvivatpongVarissara KaewchaivijitPunyanuch JindatanmanusanPiya Rujkijyanont

Published in: The application of clinical genetics (2021)

ITPA:c.94C>A and NUDT15:c.415C>T polymorphisms are common among Thai children with leukemia. A strong association with mercaptopurine-related myelotoxicity was observed among patients carrying either NUDT15:c.415C>T alone or combined with ITPA:c.94C>A.

Keyphrases

acute myeloid leukemia
bone marrow
young adults
early life