Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats.
Harzhin Hiwa AliZheen Aorahman AhmedTavga Ahmed AzizPublished in: Journal of inflammation research (2022)
The results strongly suggest the renoprotective effects of telmisartan and quercetin in combination against the nephrotoxic effect of 5-FU through decreasing the levels of KIM-1, NGAL, and cys-C, and the novel inflammatory markers of kidney injury like NLP, MLR, and PLR, as well as decreasing uric acid and restoring the TAOC. The proposed mechanism could be the additive inhibitory effect on RAS provided by both telmisartan and quercetin.