Robustness of CSF Aβ42/40 and Aβ42/P-tau181 measured using fully automated immunoassays to detect AD-related outcomes.

Antoine LeuzyNiklas Mattsson-CarlgrenNicholas C CullenErik StomrudSebastian PalmqvistRenaud La JoieLeonardo IaccarinoHenrik ZetterbergGil RabinoviciKaj BlennowShorena JanelidzeOskar Hansson

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

CSF Aβ42/p-tau181 was more robust to the effects of measurement variability, suggesting that it may be the preferred Elecsys-based measure in clinical practice and trials.

Keyphrases

cerebrospinal fluid
clinical practice
machine learning
deep learning
high throughput
metabolic syndrome
drug induced
weight loss