Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma.

Yotaro Motomura Yoshihiro UmezawaTomoyuki ArimatsuKeigo OkadaOsamu MiuraTakashi Kumagai

Published in: Clinical case reports (2022)

We report a case of fever of unknown origin in a patient with MDS associated with IgM-MGUS. The patient was positive for MYD88 mutation, and chemotherapy for LPL/WM improved the fever. Analysis of MYD88 and the effect of chemotherapy on LPL/WM finally revealed the latent LPL/WM in this case.

Keyphrases

case report
toll like receptor
locally advanced
single cell
immune response
radiation therapy