Endothelial dysfunction contributes significantly to the pathogenesis of pre-eclampsia as demonstrated by profound decrease in maternal serum VEGF levels in PE compared to normotensive pregnancy and non-pregnancy state. The pathophysiology of early-onset pre-eclampsia may be partly explained by marked reduction in free serum VEGF levels with resultant severe endothelial dysfunction.
Keyphrases
- early onset
- pregnancy outcomes
- late onset
- vascular endothelial growth factor
- endothelial cells
- preterm birth
- pregnant women
- polycystic ovary syndrome
- intellectual disability
- type diabetes
- metabolic syndrome
- birth weight
- autism spectrum disorder
- physical activity
- insulin resistance
- body mass index
- breast cancer risk