Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies.
Fernando Ferreira LeiteNatália Ferreira de SousaBruno Hanrry Melo de OliveiraGabrielly Diniz DuarteMaria Denise Leite FerreiraMarcus Tullius ScottiJosé Maria Barbosa FilhoLuís Cezar RodriguesRicardo Olímpio de MouraFrancisco Jaime Bezerra Mendonca JuniorLuciana ScottiPublished in: Molecules (Basel, Switzerland) (2023)
Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties. Among the biological properties exerted by chalcones, their ability to suppress tumors stands out, in addition to their low toxicity. In this perspective, the present work explores the role of natural and synthetic chalcones and their anticancer activity in vitro reported in the last four years from 2019 to 2023. Moreover, we carried out a partial least square (PLS) analysis of the biologic data reported for colon adenocarcinoma lineage HCT-116. Information was obtained from the Web of Science database. Our in silico analysis identified that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. We hope that the data presented in this work will help researchers to develop effective drugs to inhibit colon adenocarcinoma in future works.
Keyphrases
- electronic health record
- squamous cell carcinoma
- rheumatoid arthritis
- molecular docking
- big data
- locally advanced
- public health
- oxidative stress
- healthcare
- single cell
- adverse drug
- cell death
- molecular dynamics simulations
- rectal cancer
- machine learning
- cell proliferation
- social media
- artificial intelligence
- drug induced