The differential effects of high-fat and high-fructose diets on physiology and behavior in male rats.

These data suggest that fat accumulation and weight gain are influenced by the high-fat component of the Western-style diet. However, insulin resistance and elevated serum triglycerides are impacted more by high levels of fructose in the diet. Comparative data between a high-fat and high-fructose diet in a single study are novel and shed light on two of the individual components of a Western-style diet.