Tetrahedral framework nucleic acid nanomaterials reduce the inflammatory damage in sepsis by inhibiting pyroptosis.
Xingyu ChenJiajun HeYu XieTianxu ZhangSonghang LiYuxuan ZhaoNan HuXiaoxiao CaiPublished in: Cell proliferation (2023)
Sepsis is a highly lethal condition and is caused by the dysregulation of the body's immune response to infection. Indeed, sepsis remains the leading cause of death in severely ill patients, and currently, no effective treatment is available. Pyroptosis, which is mainly activated by cytoplasmic danger signals and eventually promote the release of the pro-inflammatory factors, is a newly discovered programmed cell death procedure that clears infected cells while simultaneously triggering an inflammatory response. Increasing evidence indicates that pyroptosis participates in the development of sepsis. As a novel DNA nanomaterial, tetrahedral framework nucleic acids (tFNAs) characterized by its unique spatial structure, possess an excellent biosafety profile and can quickly enter the cell to impart anti-inflammatory and anti-oxidation effects. In this study, the roles of tFNAs in the in vitro model of macrophage cell pyroptosis and in the in vivo model of septic mice were examined, and it was found that tFNAs could mitigate organ inflammatory damage in septic mice, wherein they reduced inflammatory factor levels by inhibiting pyroptosis. These results provide possible new strategies for the future treatment of sepsis.
Keyphrases
- acute kidney injury
- septic shock
- nlrp inflammasome
- intensive care unit
- oxidative stress
- nucleic acid
- inflammatory response
- single cell
- end stage renal disease
- induced apoptosis
- signaling pathway
- cell therapy
- anti inflammatory
- ejection fraction
- chronic kidney disease
- high fat diet induced
- stem cells
- metabolic syndrome
- type diabetes
- adipose tissue
- cell proliferation
- current status
- nitric oxide
- peritoneal dialysis
- patient reported outcomes
- lipopolysaccharide induced
- mesenchymal stem cells
- smoking cessation
- wild type
- lps induced