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S100 Calcium-Binding Protein A8 Functions as a Tumor-Promoting Factor in Renal Cell Carcinoma via Activating NF-κB Signaling Pathway.

Shu-Hui WangYan-Jie XiaJing YuChun-Yan HeJie-Ru HanJi-Xiang Bai
Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2023)
Overall, S100A8 knockdown restrained RCC malignant biological properties, which was associated with the deactivation of the NF-κB signaling pathway. This present study demonstrates new insights that S100A8 may be a potential therapeutic target in RCC.
Keyphrases
  • signaling pathway
  • renal cell carcinoma
  • pi k akt
  • binding protein
  • induced apoptosis
  • epithelial mesenchymal transition
  • cell proliferation
  • lps induced
  • immune response
  • toll like receptor