S100 Calcium-Binding Protein A8 Functions as a Tumor-Promoting Factor in Renal Cell Carcinoma via Activating NF-κB Signaling Pathway.

Shu-Hui WangYan-Jie XiaJing YuChun-Yan HeJie-Ru HanJi-Xiang Bai

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2023)

Overall, S100A8 knockdown restrained RCC malignant biological properties, which was associated with the deactivation of the NF-κB signaling pathway. This present study demonstrates new insights that S100A8 may be a potential therapeutic target in RCC.

Keyphrases

signaling pathway
renal cell carcinoma
pi k akt
binding protein
induced apoptosis
epithelial mesenchymal transition
cell proliferation
lps induced
immune response
toll like receptor