Association of Bethesda category and molecular mutation in patients undergoing thyroidectomy.
Marco Antonio MascarellaMagdalena PeevaVeronique-Isabelle ForestMarc Philippe PusztaszeriGalit AviorMichael TamiliaAlex M MlynarekMichael P HierRichard J PaynePublished in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2021)
BRAFV600E mutations were associated with thyroid cancer subtypes known to be more aggressive whereas RAS and EIF1AX mutations, copy number alterations, and GEP were related to Bethesda categories III and IV. These findings may help thyroid specialists better identify aggressive thyroid nodules associated with indeterminate Bethesda categories.