Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy.
Maxime Tremblay-GravelKenzo IchimuraKermshlise PicardYumeko KawanoAnnika M DriesFrancois HaddadNeal K LakdawalaMatthew T WheelerVictoria N ParikhPublished in: Circulation. Genomic and precision medicine (2022)
cardiomyopathy is associated with early intrinsic atrial myopathy reflected by high AF prevalence and reduced LA contractile strain, even in the absence of LV dysfunction and LA dilation. Whether LA strain can be used as a monitoring strategy to detect and mitigate AF complications requires validation.
Keyphrases
- atrial fibrillation
- heart failure
- left atrial
- catheter ablation
- left ventricular
- oral anticoagulants
- left atrial appendage
- late onset
- risk factors
- direct oral anticoagulants
- oxidative stress
- percutaneous coronary intervention
- cardiac resynchronization therapy
- muscular dystrophy
- acute myocardial infarction
- hypertrophic cardiomyopathy
- aortic stenosis
- smooth muscle
- early onset
- myasthenia gravis