Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.
Dan-Dan LiuPiao LuoLiwei GuQian ZhangPeng GaoYongping ZhuXiao ChenQiuyan GuoJunzhe ZhangNan MaJi-Gang WangPublished in: Journal of neuroinflammation (2021)
Cel exhibited neuroprotective and anti-inflammatory effects by targeting HSP70 and NF-κB p65 and directly binding to HMGB1 in cerebral I/R injury.