Prolonged mechanical ventilation worsens sepsis-induced diaphragmatic dysfunction in the rat.

Matthieu Le DinhSerge CarreiraJulie ObertGhislaine Gayan-RamirezBruno RiouMaud BeuvinThomas SimilowskiCatherine CoiraultAlexandre Demoule

Published in: PloS one (2018)

Prolonged (12 h) MV exacerbated sepsis-induced decrease in diaphragm performance. Systemic and diaphragmatic overproduction of pro-inflammatory cytokines may contribute to diaphragm weakness.

Keyphrases

mechanical ventilation
intensive care unit
acute respiratory distress syndrome
high glucose
diabetic rats
oxidative stress
acute kidney injury
drug induced
respiratory failure
endothelial cells
extracorporeal membrane oxygenation