Navigating the Cytokine Seas: Targeting Cytokine Signaling Pathways in Cancer Therapy.
Noyko StanilovTsvetelina V VelikovaSpaska A StanilovaPublished in: International journal of molecular sciences (2024)
Cancer remains one of the leading causes of morbidity and mortality worldwide, necessitating continuous efforts to develop effective therapeutic strategies. Over the years, advancements in our understanding of the complex interplay between the immune system and cancer cells have led to the development of immunotherapies that revolutionize cancer treatment. Cytokines, as key regulators of the immune response, are involved in both the initiation and progression of cancer by affecting inflammation and manipulating multiple intracellular signaling pathways that regulate cell growth, proliferation, and migration. Cytokines, as key regulators of inflammation, have emerged as promising candidates for cancer therapy. This review article aims to provide an overview of the significance of cytokines in cancer development and therapy by highlighting the importance of targeting cytokine signaling pathways as a potential therapeutic approach.
Keyphrases
- cancer therapy
- papillary thyroid
- signaling pathway
- drug delivery
- immune response
- squamous cell
- oxidative stress
- transcription factor
- epithelial mesenchymal transition
- childhood cancer
- stem cells
- inflammatory response
- toll like receptor
- quality improvement
- cell proliferation
- reactive oxygen species
- endoplasmic reticulum stress
- cell therapy