D-Mannose prevents bone loss under weightlessness.

Ranli GuHao LiuMenglong HuYuan ZhuXuenan LiuFeilong WangLikun WuDanyang SongYunsong Liu

Published in: Journal of translational medicine (2023)

D-mannose protected against bone loss and UTIs in rats under weightlessness. The bone protective effects of D-mannose were mediated by inhibiting osteoclast cell fusion. Our findings provide a potential strategy to protect against bone loss and UTIs during space missions.

Keyphrases

bone loss
single cell
signaling pathway
stem cells
mouse model
risk assessment
human health