Marcytoglobosins A and B, Cytochalasans From a Marine Sponge Associated Chaetomium globosum 162105 Fungus.
Xian-Xian MiaoLi-Li HongHong-Yan LiuRu-Yi ShangWei-Hua JiaoShi-Hai XuHou-Wen LinPublished in: Chemistry & biodiversity (2024)
Two new cytochalasans, marcytoglobosins A (1) and B (2) were isolated from the marine sponge associated fungus Chaetomium globosum 162105, along with six known compounds (3-8). The complete structures of two new compounds were determined based on 1D/2D NMR and HR-MS spectroscopic analyses coupled with ECD calculations. All eight isolates were evaluated for their antibacterial activity. Among them, compounds 3-8 displayed antibacterial effects against Staphylococcus epidermidis, Bacillus thuringiensis, Pseudomonas syringae pv. Actinidiae, Vibrio alginolyticus, and Edwardsiella piscicida with minimum inhibitory concentration (MIC) values ranging from 10 to 25 μg/mL.
Keyphrases
- biofilm formation
- high resolution
- staphylococcus aureus
- pseudomonas aeruginosa
- mass spectrometry
- magnetic resonance
- candida albicans
- silver nanoparticles
- molecular docking
- escherichia coli
- molecular dynamics
- ms ms
- density functional theory
- molecular dynamics simulations
- cystic fibrosis
- bacillus subtilis
- monte carlo