A Cross-Trait, Mendelian Randomization Study to Investigate Whether Migraine Is a Risk Factor for Multiple Sclerosis.

Mary K HortonSarah C RobinsonXiaorong ShaoHong QuachDiana QuachVidhu ChoudharyKalliope H BellesisPete DorinJin MeiTerrence ChinnTravis J MeyersNandini BakshiJacqueline F MarcusEmmanuelle WaubantCatherine A SchaeferLisa F Barcellos

Published in: Neurology (2023)

Our findings do not support migraine as a causal risk factor for MS. Several genetic variants, particularly in the MHC, may account for some of the overlap. It seems likely that migraine within the context of MS is a result of MS. Identifying what increases risk of migraine within MS might lead to improved treatment and quality of life.

Keyphrases

multiple sclerosis
mass spectrometry
ms ms
white matter
dna methylation
combination therapy