LHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling.

Qiang WangJinrong LiaoZhiyong HeYing SuDong LinLing XuHai-Peng XuJinghui Lin

Published in: OncoTargets and therapy (2020)

LHX6 down-regulation may induce EGFR-TKIs resistance and increase the migration ability of HCC827/ER cells via activation of the Wnt/β-catenin pathway.

Keyphrases

induced apoptosis
epidermal growth factor receptor
small cell lung cancer
cell cycle arrest
stem cells
cell proliferation
tyrosine kinase
signaling pathway
endoplasmic reticulum stress
cell death
pi k akt