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Unravelling the role of dipeptidyl peptidases-8/9 (DPP-8/9) in inflammatory osteoporosis: a comprehensive study investigating chrysin as a potential anti-osteoporotic agent.

Syed Sufian AhmadFaraha AhmedMohd Mumtaz AlamSayeed AhmadMohammad Ahmed Khan
Published in: The Journal of pharmacy and pharmacology (2024)
This study highlights the role of DPP-8/9 in inflammation-induced osteoporosis. Following inhibition of DPP-8/9, we observed improved bone markers with preservation of trabecular bone mineral density in rats. Additionally, chrysin demonstrated potential as an anti-DPP-8/9 agent, suggesting its viability for future therapeutic interventions in DPP-8/9-related inflammatory diseases.
Keyphrases
  • bone mineral density
  • postmenopausal women
  • body composition
  • oxidative stress
  • drug induced
  • climate change
  • soft tissue